Among them the CSNK1A1–PTK7 interaction maybe related to the synapse dysfunction and Wnt signaling pathways, the HNRNPU–NEDD4L interaction might has an impact on the impairment of cognitive and memory abilities in AD, and the CD80–PLCG2 interaction maybe associated with both microglia and inflammatory. This evidence concerns the gene NEDD4L and Alzheimer disease.