Furthermore, the native state of the detected antigen is not limiting when using these tools, as monoclonal antibodies bind also the denatured form of HER2 protein, shown on WB of the cancer cell lysates probed with the anti-human HER2/70.27.58 mAb (Fig. 2D) and IF of the formaldehyde-fixed cells. This evidence concerns the gene ERBB2 and cancer.