Moreover, we found that both Vk*Che-1 and Vk*Myc transgenic mouse model, which, through activating c-Myc oncogene in maturing B cells, induces MM transformation [13], also showed higher levels of the miR-590-3p in their bone marrow than control littermates (Fig. 2B and Supplementary Fig. S5A). This evidence concerns the gene MYC and Miyoshi myopathy.