In the four gene modules enriched for immune processes (i.e., spots F, K, L, and R, see Supplementary Table S5), transcriptome perturbations occurred in the very early days of postnatal life except in module L. The gene clusters F and R, unique for MDD and SCZ, respectively, were enriched for biological processes such as regulation of immune response, cellular defense response, negative regulation of neuronal death, positive regulation of transcription by RNA polymerase II, negative regulation of TNF production and signal transduction. This evidence concerns the gene TNF and major depressive disorder.