PTH and hypoparathyroidism: Interestingly, recombinant PTH was reported to increase bone density, reverse skeletal abnormalities, and improve the bone microstructure of patients with hypoparathyroidism.116 A combination of intermittent PTH and antiresorptive agents has been widely investigated and may be an alternative option for patients previously treated with bisphosphonates.117 Osteoblasts and osteocytes express the type-1 PTH receptor (PTH1R) and thus are the target cells of PTH.118