Denosumab is a human monoclonal IgG2 antibody against RANKL and has been approved for the treatment of osteoporosis in postmenopausal women, women with breast cancer taking aromatase inhibitors, and men at high risk of fracture, such as prostate cancer patients undergoing androgen deprivation therapy.420–422 In addition, denosumab has been approved for treating GC-induced osteoporosis in both women and men at high risk of fracture. This evidence concerns the gene CYP19A1 and Familial prostate cancer.