IL10 and type 1 diabetes mellitus: As a metabolic disorder, the influence of diabetes on bone tissues and cells is complex.297,298 T1DM patients exhibit enhanced systemic inflammation, bone loss, and fracture risks, in which IL-10 is essential in promoting osteoblast maturation.299 Boys with T1DM exhibited significantly lower BMD at several sites than boys without T1DM, while these obvious differences were not observed in girls with T1DM.