In the current study, through siRNA screening we have identified that 8-Oxoguanine DNA Glycosylase (OGG1) and Poly(ADP-Ribose) Glycohydrolase (PARG) are fundamental for HeLa and HNSCC cell survival post-irradiation with high-LET PBT. The gene discussed is OGG1; the disease is head and neck squamous cell carcinoma.