TNF and alkaline phosphatase measurement: Meanwhile, serum concentrations of the pro-inflammatory factors CRP, TNF-α, IL-6, and IL-1β were higher in the AP patients than the healthy controls by 195.7% (p < 0.01), 24.5% (p < 0.01), 16.8% (p < 0.05), and 5.6% (p < 0.05), respectively.