While activation of many of these processes was observed in patients with severe COVID-19, inflammasome assembly was highly enriched in patients with Delta phase COVID-19, with genes encoding multiple pattern recognition receptors (NLRP6, NLRP1, TLR6, TLR4, AIM2, TREM2), Pyrin (MEFV), caspase recruitment domain proteins (CARD8), cytoplasmic stress granules (DDX3X), and phospholipase C (PLCG2) comprising the core pathway enrichment set. Here, CARD8 is linked to COVID-19.