Compared to conventional CAR-T cells, CAR-ss-T cells produced higher levels of interferon-γ (IFN-γ), IL-2, tumor necrosis factor-α (TNF-α) and granzyme B (GZM) against MSLN-expressing HGC27 and MKN45 tumor cells (Fig. 2C and D). The gene discussed is GZMB; the disease is neoplasm.