For example, SERTA domain containing 3 (SERTAD3) has an antiviral ability to IAV and Zika virus (ZIKV) by blocking the assembly of viral RNA polymerase complex and inducing proteasomal degradation of ZIKV capsid protein, respectively [12, 13]; Cholesterol-25-hydroxylase (CH25H) broadly inhibits viral entry by production of 25-hydroxycholesterol (25HC) [14–16]; Interferon-induced transmembrane proteins (IFITMs) inhibit infection of diverse enveloped viruses by blocking the fusion of the viral-cellular membrane to hinder the virus entering the cytoplasm [17–20]. The gene discussed is CH25H; the disease is infection.