APOA1 and endothelial dysfunction: Natural HDL, composed primarily of a core containing cholesteryl esters and triglycerides, enveloped by phospholipids (PL) and apolipoprotein A1 (apoA1), is renowned as a “vascular scavenger.”[141] HDL has been found to prevent endothelial dysfunction and facilitate reverse cholesterol transport (RCT), thereby inhibiting the formation of foam cells and ultimately delivering remarkable anti‐atherosclerotic effects.[142]