GP6 and atherosclerosis: Especially, they are the key mediator for plaque rupture and erosion, thrombosis, and plaque healing.[40] Platelet receptors are potential targets for atherosclerosis, including integrin glycoprotein (GP) IIb/IIIa, GPVI, thrombin receptors, etc.[41] GP IIb/IIIa highly expressed on the surface of activated platelets can bind with fibrinogen, and further promote platelet aggregation.