SGs are cytoplasmic membrane‐less RNP aggregates that form in response to various environmental stressors such as heat shock, oxidative stress, osmotic stress, or nutrient starvation.[37, 38] Previous studies have reported that SGs influence the malignant behavior of tumors, particularly their invasion, migration, and drug resistance.[12, 16] Our research showed that ICC stimulated with E. coli exhibited enhanced migratory ability and chemoresistance. This evidence concerns the gene RNPC3 and intrahepatic cholangiocarcinoma.