For example, circVAMP3 inhibits the expression of the Myc proto‐oncogene protein by inhibiting the translation of c‐Myc through SGs.[19]E. coli‐stimulated ICC cells show abnormal activation of the NF‐κB pathway, which plays an important regulatory role in the metastasis and drug resistance of malignant tumors, including ICC.[22] Note that cGLIS3‐mediated SGs cause the continuous activation of the NF‐κB pathway. This evidence concerns the gene NFKB1 and intrahepatic cholangiocarcinoma.