Poor tumor tissue penetration is a major challenge and bottleneck for NPs in achieving efficacious anticancer therapy.[19] TfR‐1, with its distinctive sorting and recycling functions, has emerged as an attractive receptor for orchestrating targeted drug delivery, especially in scenarios involving transcytosis‐mediated delivery.[20] This study highlights the pivotal role played by TfR‐1‐mediated transcytosis in facilitating profound NP penetration into solid tumor tissue. This evidence concerns the gene TFRC and neoplasm.