PLEC and Vascular dilatation: Finally, there were 3 patients with variants in the PLEC gene, all of whom manifested blisters in the first hours of life; their lesions remained mainly in extremities, with the presence of mild milia, but they evolved with rather normal weight and stature; two of the patients were submitted to esophageal dilatation due to stenosis and one had pseudo syndactyly on her feet.