Pathogenic deposits of TDP-43 have been identified in postmortem samples in different brain regions and spinal cord of an increasing number of neurodegenerative disorders, including the great majority of ALS cases, around 50% of all FTD cases, and all LATE cases (limbic-predominant age-related TDP-43 encephalopathy) (Nelson et al., 2019), a new dementia entity that overlaps with Alzheimer's disease (AD) and occurs particularly in old age. The gene discussed is TARDBP; the disease is Alzheimer disease.