TARDBP and amyotrophic lateral sclerosis: Indeed, alterations in myelin and oligodendrocytes have been previously reported in other TDP-43 and FUS mouse models (Guzman et al., 2020; Heo et al., 2022; Ho et al., 2021; Wang et al., 2018), and ALS patients (Kang et al., 2013), with premorbid white matter abnormalities recently found in ALS patients (Thompson et al., 2023).