The development of sequencing techniques and increasingly accessible screening in the clinic has identified rare TARDBP mutations also in clinical neurodegenerative pathologies other than ALS and FTD, such as semantic primary progressive aphasia (svPPA) (Caroppo et al., 2016; Gelpi et al., 2014), flair arms (Moreno et al., 2015), classical Parkinson's disease and atypical Parkinsonism (progressive supranuclear palsy and corticobasal syndrome) (Chen et al., 2021; Tiloca et al., 2022) and autosomal dominant myopathy (Zibold et al., 2023). Here, TARDBP is linked to Classical progressive supranuclear palsy.