Moreover, despite the low prevalence of TARDBP mutations, there are a few reported cases of ALS patients carrying homozygous mutations (p.A382T and p.G294V) that do not seem to lead to overtly severe phenotypes (Borghero et al., 2011; Cannas et al., 2013; Corrado et al., 2020; Lombardi et al., 2023). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.