The luciferase activity of MET-WT was reduced in lncRNA CHROMR-depleted DLBCL cells and enhanced in lncRNA CHROMR-overexpressed DLBCL cells, and the increase was abolished by miR-27b-3p mimics transfection by dual luciferase reporter assay, suggesting that lncRNA CHROMR stabilizes the expression of MET by sponging with miR-27b-3p. This evidence concerns the gene CHROMR and diffuse large B-cell lymphoma.