All of them demonstrated that different anti-IL-5 biologics promoted improvement compared to the placebo arm in various evaluated parameters, including quality of life, nasal obstruction, the need for systemic corticosteroid use to relieve nasal symptoms, olfaction, polyp size, opacification on computed tomography and the need for polyp surgery.57, 58, 59 In fact, only Benralizumab and Mepolizumab were analyzed for this purpose. The gene discussed is IL5; the disease is polyp.