IL5 and congenital rubella syndrome: Mepolizumab, the only anti-IL-5 with an established indication and approval for CRS treatment, was assessed through the SYNAPSE study, where among 854 patients, 407 in the Intention-To-Treat (ITT) population were randomized, with 206 receiving Mepolizumab and 201 in the placebo arm, for a 52-week follow-up period.