Direct exposure of the airway epithelium to S. aureus, for example, increases the expression of IL-33 and TSLP, which induce the production of cytokines such as IL-5 and IL-13, playing an important role in the onset and/or maintenance of type 2 inflammation in CRSwNP.2, 7. The gene discussed is IL5; the disease is chronic rhinosinusitis with nasal polyps.