Although there is still no consensus on its diagnosis, the most accepted criteria are the 5 elements established by Bent and Kuhn11: (1) Presence of chronic rhinosinusitis with nasal polyps; (2) IgE-mediated hypersensitivity to fungi; (3) Eosinophilic mucin (often with intense eosinophilic degranulation and the formation of Charcot-Leyden crystals); (4) Presence of non-invasive fungal structures, and (5) Radiological findings characteristic of fungal presence, such as compact hyperdensities in the paranasal sinuses (combination of various metals concentrated by fungi).2 The gene discussed is IGHE; the disease is Nasal polyposis.