IGHE and allergic rhinitis: Dupilumab also led to a reduction in the concentrations of eosinophilic inflammation biomarkers: serum IgE, eotaxin-3, periostin, and TARC; tissue IgE, eosinophilic cationic protein, eotaxin-2, PARC, IL-13, periostin, and IL-5.86, 87 However, the diagnosis of Allergic Rhinitis or the number of eosinophils in the serum does not interfere with the intensity of the response to Dupilumab, the frequency of systemic corticosteroid use, or the indication for sinonasal surgery.88, 89, 90