Although more than 70 genes have been reported today in puberty, the ones mainly associated with idiopathic or familial CPP are the gain-of-function mutations in KISS1, KISS1R, and PROKR2, and the loss-of-function variant in paternally inherited allele in the MKRN3 and the DLK1 genes [1, 6–10]. Here, PROKR2 is linked to central precocious puberty.