AKR1A1 and keratoconus: In addition, cultures were characterized in-depth for metabolic gene families described to be expressed by ex vivo human skin: cytochrome P450s, alcohol dehydrogenases, aldehyde dehydrogenases, arachidonate lipoxygenases and hydroxysteroid dehydrogenases, sulfotransferases and glutathione s-transferases, of which 79 enzymes were expressed in the described RhS and adipose-RhS (Supplementary Materials, Fig. S1A) [5] out of the 98 enzymes described previously in ex vivo human skin, RhS, RhE and KC monolayers (Supplementary Materials, Fig. S1B) [6].