MPO and cancer: Using the TCGA data set for pancreatic adenocarcinoma with the TIMER2.0 XCell algorithm [33], we observe a significantly positive correlation of MPO gene expression with immunosuppressive subsets of immune cells including T regulatory cells, Th2 CD4+ T cells, M2 macrophages and cancer associated fibroblasts (Fig. S10 a–e), and a negative correlation with anti-tumor Th1 CD4+ T cells (Fig. S10f).