Specifically, the DEGs involved in neuronal transcriptional activity mainly include Mnd1, Nr1i3, Macc1, Npas4, Atf3, Nr4a2, Junb, FosB, Egr3, Nr4a3, Egr4 and were all down‐regulated in the OB of 3xTg‐AD mice (Figure 5B). Here, NR4A2 is linked to Alzheimer disease.