Specifically, the DEGs involved in neuronal transcriptional activity mainly include Mnd1, Nr1i3, Macc1, Npas4, Atf3, Nr4a2, Junb, FosB, Egr3, Nr4a3, Egr4 and were all down‐regulated in the OB of 3xTg‐AD mice (Figure 5B). The gene discussed is MACC1; the disease is Alzheimer disease.