Sullivan et al. have evaluated markers of immune activation on total CD4 and CD8 T cell populations in adults and reported increased frequencies of CD38+HLA-DR+ CD4 and CD8 T cells in PWH with active TB, compared with PWH with LTBI and with no evidence of Mtb infection.14 Our findings of increased frequencies of HLA-DR+CD38+Ki67+ and HLA-DR+CD38+Ki67– and CD4 T cells in people with TB are consistent with this previous report. This evidence concerns the gene CD4 and tuberculosis.