To determine whether depletion of HIV-specific CD4 and CD8 T cells in people with TB is associated with altered phenotypic profiles, we evaluated expression of activation markers (CD38, HLA-DR, and Ki67), apoptosis (active caspase-3), and cytotoxicity (granzyme B and perforin) on CD4 and CD8 T cells. Here, CD8A is linked to tuberculosis.