CD8A and tuberculosis: Taken together, these data indicate that despite evidence of increased immune activation and cytotoxicity on total CD4 and CD8 T cells in PWH and TB, these phenotypic modifications are not evident on HIV-specific CD4 and CD8 T cell populations and suggest that mechanisms other than immune activation and apoptosis may underpin the depletion of HIV-specific CD4 and CD8 T cells in PWH and TB.