CD4 and tuberculosis: Loss of HIV-specific CD8 T cells in PWH has been associated with failure of T cell immunity and HIV disease progression.32 Moreover, HIV-specific CD8 T cells with cytotoxic capacity have been associated with enhanced killing of autologous HIV-infected CD4 T cells and slower HIV disease progression.33–36 Depletion of HIV-specific CD8 T cells with cytotoxic capacity in people with TB may lead to poorer CD8 T cell–mediated control of HIV replication, which may contribute to increased HIV viral loads that have been described in people with TB.6,7