PLK1 and colorectal carcinoma: Our preliminary exploration of BI-2536, a PLK-1 inhibitor, revealed that while the growth inhibitory effects were similar in CRC cells kept at pH 7.4 compared to those exposed to pH 6.5 (even less pronounced for the latter), the reappearance of cell growth following drug removal was notably reduced in the presence of acidosis (Appendix Fig. S2).