In this study, cyclin-dependent kinase 5 (Cdk5) was identified as a target of lncRNAs; nuclear-enriched abundant transcript 1 (NEAT1) and HOTAIR. Notably, Cdk5 is a primary focal mediator of tau and amyloid pathologies and is aberrantly hyperactivated in AD. The gene discussed is MAPT; the disease is Alzheimer disease.