Computational analyses of lncRNAs as regulators of transcription factor-gene target relationships have resulted in the identification of several lncRNA-transcription factor-gene target axes with a close association with glioblastoma progression, including HOTAIR-MAX interacting protein 1CD 58-protein kinase C epsilon (HOTAIR-MXI 1-CD 58-PRKCE) and HOTAIR-activating transcription factor 5-neural cell adhesion molecule 1 (HOTAIR-ATF 5-NCAM 1) triplets (Li et al. 2016b). This evidence concerns the gene HOTAIR and glioblastoma.