HOTAIR and Parkinson disease: Correspondingly, repression of HOTAIR expression and the beneficial changes in miR-126-5p/RAB3IP signaling have been reported to inhibit the loss of tyrosine hydroxylase (TH)-positive cells and reduce the abundances of α-synuclein-positive cells, in conjugation with significant attenuation of PD-associated decline in motor and behavioral functions (Lin et al. 2019).