Thus, HOTAIR-miR-126-5p-GLS signaling may have significant effects on multiple aspects of glutamine metabolism, aberrant angiogenesis, cellular invasiveness, and temozolomide resistance (see also “HOTAIR as a Mediator of Chemoresistance in Gliomas” section) in glioma pathophysiology (Liu et al. 2018a). Here, HOTAIR is linked to glioma.