Similarly, pro-inflammatory actions of hyperactivated HOTAIR have been reported to underlie inflammatory injury, oxidative damage, and cellular apoptosis in spinal cord ischemia–reperfusion injury, possibly in a high mobility group box 1 (HMGB-1)- and NF-κB-dependent manner (Wang et al. 2022c). The gene discussed is HMGB1; the disease is spinal cord ischemia.