HOTAIR and neurodegenerative disease: Next, the evidences for involvement of HOTAIR signaling in the pathophysiology of a plethora of non-cancerous neuronal disorders, including neurodegenerative diseases (e.g., Alzheimer’s disease, Parkinson’s disease and multiple sclerosis), traumatic, ischemic and hypoxic brain injuries, and neuropsychiatric conditions, are discussed (Table 2).