As an example, tau-PET signal in the right globus pallidus internus showed the strongest negative regression factor with DaT availability in the right posterior putamen of patients with 4R-tauopathies (β =  − 0.464, p = 0.006, Durbin-Watson statistics = 1.824; Fig. 2c), whereas this association was not observed in patients with α-synucleinopathies (β =  − 0.178, p = 0.637, Durbin-Watson statistics = 1.810; Fig. 2c). The gene discussed is MAPT; the disease is synucleinopathy.