Regarding the regional associations of tau-PET signal in typical target regions of tau accumulation in 4R-tauopathies and striatal DaT binding, we found that only regions of the nigrostriatal pathway and regions involved in direct or indirect pathways of the basal ganglia revealed a significant negative correlation between tau-PET and DaT-SPECT (Fig. 2). The gene discussed is MAPT; the disease is tauopathy.