INS and diabetes mellitus: It is noteworthy that in one Finnish family, of the 11 family members who were heterozygous carriers of a loss-of-function KATP channel mutation (ABCC8-E1506K), all reported symptoms of hypoglycaemia in childhood, four had overt diabetes and five had glucose intolerance with severely blunted first-phase glucose-stimulated insulin secretion in adult life [15], an incidence substantially higher than in the general population.