Intriguingly, exploiting the Broad Institute’s Cancer Dependency Map (DepMap) dataset (https://depmap.org/), which includes genome-scale CRISPR-Cas9 screens in over 1000 cancer cell lines, revealed that dependency on UBE2J2 or UBE2K significantly correlated with a dependency on MARCH5 across all cancer cell lines; and similar trends were observed within AML cell lines (Fig. 1c). Here, UBE2J2 is linked to acute myeloid leukemia.