LGALS9 and melanoma: We firstly explored the synergistic effects of PTT and silencing Gal-9 to achieve photothermal immunotherapy treating melanoma with a novel integrated nanostructure FSGG (Folic acid-modified and gold nanorod-linked iron oxide/silica core/shell nanostructure) /siGal-9 that is composed of gold nanorods, glucose-modified iron oxide-silica core/shell, and Gal-9-specific siRNA.