The anti-tumor effects were highest when the melanoma-bearing mice received a combination treatment with FSGG/siGal-9 plus laser irradiation plus magnet field (“FSGG/siGal-9+Laser+M”), which further suppressed tumor growth (Fig. 5c) and also was confirmed by the tumor weight (Fig. 5d) that was remarkably smaller (0.49 ± 0.05 g) than that in the mice receiving single treatment with the photothermal effects (“FSGG/siGL2+Laser+M”, 0.86 ± 0.10 g) or gene silencing of Gal-9 (“FSGG/siGal-9+M”, 0.76 ± 0.04 g). Here, LGALS9 is linked to melanoma.