Moreover, Li et al.40 also in mice model showed that the proteasome inhibitor bortezomib can partially attenuate abdominal aortic aneurysm model formation by modulating the infiltration of T lymphocytes through the regulation of ICAM-1 mRNA expression, which is controlled by the activation of the NF-κB signaling pathway40. The gene discussed is NFKB1; the disease is abdominal aortic aneurysm.