So, while the KD and BHB itself have significant effects on LTP, synaptic plasticity enzymes p-ERK and p-CREB, and BDNF expression in females that relate to the early phase of AD known as mild cognitive impairment (MCI), their impact was not as strong on what could be considered the later and more integrative phases of the disease. This evidence concerns the gene BDNF and Alzheimer disease.