ADH4 and liver cancer: In Huh7 liver cancer cell, Karyopherin subunit alpha 2 (KPNA2), ras-related GTP binding C (RRAGC), and Secreted phosphoprotein 1 (SPP1) were overexpressed compared to THLE2 cell, while formimidoyltransferase cyclodeaminase (FTCD), alcohol dehydrogenase 4 (ADH4), and Annexin A10 (ANXA10) were down-regulated compared to normal liver cell (Fig. 4H–M).