APOA1 and Alzheimer disease: There was evidence of positive associations between higher AD liability and the following lipid metabolites across the life course: serum total cholesterol, very-low density lipoprotein (VLDL) cholesterol, remnant cholesterol, low-density lipoprotein (LDL) cholesterol, esterified cholesterol, free cholesterol, apolipoprotein B, ratio of apolipoprotein B to apolipoprotein A1, and sphingomyelins.