RHO and retinal degeneration: The localization of rhodopsin in photoreceptor cells was examined in retinas from 2-week-old mice (Fig. 5E), an early time point where rhodopsin and ROS discs are beginning to form at a rapid rate in B6 mice43,44 and retinal degeneration is minimal in heterozygous mutant mice, and in 1-month-old mice (Fig. 5F), where rhodopsin expression and ROS length have stabilized in B6 mice43,44 and retinal degeneration is significant.