RHO and retinal degeneration: Moreover, interventions that promote the proper folding of mutant rhodopsin (e.g., enhancing heat shock response or use of chaperones73,89,90) or enhance the clearance of misfolded rhodopsin mutants (e.g., increasing autophagy or proteasome activity91–94), have all shown beneficial effects in reducing retinal degeneration in mice expressing the P23H rhodopsin mutant.