In CCA, METTL3 has been indicated to upregulate the expression of oncogenes such as AKR1B10, HLF and NFAT5, which consequently promote growth, self-renewal, metastasis and glycolysis of ICC cells [66, 67], and is proven to be correlate with poor prognostics [68]. Here, METTL3 is linked to cholangiocarcinoma.