ZIC2 and cholangiocarcinoma: Previous study validated that IGF2BP1 was the crucial protein in stabilizing the RNA of c-Myc and ZIC2 in CCA, thereby promoting iCCA growth and suppressing its senescence through the c-Myc/p16 axis, while inducing metastasis via activating the ZIC2/PAK4/AKT/MMP2 axis.