In line with the high proportion of Tregs observed in acute HSP, IL-10 serum levels tended to be higher in acute than in remittent HSP (12.32 pg/ml [3.86; 23.33] vs. 6.36 pg/ml [2.95; 22.68], p = 0.089) or HCs (4.59 pg/ml [2.76; 10.1], p = 0.403) (Fig. 1B, Additional file 1: Table S1). Here, IL10 is linked to hereditary spastic paraplegia.