In contrast, genes that were significantly downregulated (adjusted P-value < 0.05) in APL blasts were enriched for immune response-related functions, including antigen processing and presentation (PSMB9, PSMB10, and CTSS), MHC class II protein complex (CD74, HLA-DPA1, and HLA-DRA), regulation of cytokine production (CLEC7A, CCR2, and CCL3), and response to interferon-gamma (IRF8, IRF5, and IFI30) (Fig. 1f and Supplementary Fig. 3b). This evidence concerns the gene CTSS and acute promyelocytic leukemia.