Conversely, oncogenic TFs (e.g., RB1, HIF1A, and MAX), epigenetic regulators (e.g., SMAD4, MBD1, YY1, and SP3), and cell proliferation-associated TFs (e.g., RNF6, ELF2, and TOP2B) were activated in APL blasts compared to normal GMPs (Fig. 1g). This evidence concerns the gene RNF6 and acute promyelocytic leukemia.