DNMT3A and acute promyelocytic leukemia: The analysis revealed that significantly upregulated genes (adjusted P-value < 0.05) in APL blasts were of functional relevance to several key processes, including HSC self-renewal/differentiation (RUNX1, MYC, and JAG1), histone modification (EP300) and DNA methylation (DNMT3A and MBD1), cell cycle arrest and cell growth (CDK6, CCNA1, and WT1), as well as the response to endoplasmic reticulum stress and unfolded protein (XBP1, ATF6, and USP14) (Fig. 1e and Supplementary Fig. 3a).