We identified eleven genes (SKAP2, IL1RAP, PLD1, HOPX, TRIM47, MAP2K1, TNFSF4, OLFML2A, P2RY14, NPTX2, and RALA) to construct the APL stemness score, which showed a significant correlation with the proportion of APL stem-like cells (Pearson’s correlation = 0.802; P < 0.0001). Here, SKAP2 is linked to acute promyelocytic leukemia.