RUNX2 and acute promyelocytic leukemia: This analysis also revealed that RUNX1, RUNX2, and interferon-related factors (i.e., STAT1 and FOS) might be involved in the GMP-like differentiation trajectory, while CEBP family members (CEBPA, CEBPB, and CEBPE), MAFB, JUNB, and JUND were likely associated with the lineage decision towards the S100hiGMP-like APL blasts (Fig. 2f).