Notably, we observed a significant downregulation of APL stemness CD markers (such as CD200, CD34, FCGR2A/CD32, CD9, and IL3RA/CD123) and TFs (such as HHEX, MYC, JAG1, and ERG) in primitive cell types (Fig. 6g and Supplementary Data 10). This evidence concerns the gene IL3RA and acute promyelocytic leukemia.