We observed that longitudinal changes in plasma NTA-tau were associated with over time changes in atrophy (β[95%CI] = -0.07 [-0.11, -0.03], p < 0.001, R2 = 0.21) in cognitive scores for both MMSE (β[95%CI] = -0.48[-0.87, -0.08], p < 0.05, R2 = 0.20) and mPACC (β[95%CI] = -0.14[-0.27, 0], p < 0.05, R2 = 0.20) (Fig. 8A-C). The gene discussed is MAPT; the disease is Atrophy.