MAPT and Mental deterioration: In BioFINDER-2, higher baseline plasma NTA-tau levels were associated with a more pronounced cognitive decline, both looking at MMSE (β[95%CI] = -1.04[-1.27, -0.81], p < 0.001, R2 = 0.28) and mPACC (β[95%CI] = -0.42[-0.52, -0.32], p < 0.001, R2 = 0.27) (Fig. 6A, B and Table 3).