MAPT and Alzheimer disease: In participants within the AD continuum (i.e., CU+ , MCI+ and AD+), plasma NTA-tau was negatively associated with both MMSE (BioFINDER-2: β[95%CI] = -1.98[-2.34, -1.61], p < 0.001, R2 = 0.20; BioFINDER-1: β[95%CI] = -0.52[-0.71, -0.33], p < 0.001, R2 = 0.13) and mPACC (BioFINDER-2: β[95%CI] = -0.72[-0.89, -0.55], p < 0.001, R2 = 0.18; BioFINDER-1: β[95%CI] = -0.41[-0.54, -0.28], p < 0.001, R2 = 0.17) (Fig. 4A-D and Table 2).