Alzheimer’s disease (AD) is neuropathologically defined by the abnormal accumulation of amyloid-β (Aβ) peptides into extracellular Aβ plaques and intraneuronal fibrillary aggregates comprised of phosphorylated tau protein referred to as neurofibrillary tangles (NFTs) [1, 2]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.