It is also detectable in published datasets of RNAPII ChIP-sequencing experiments performed in DLD-1 colorectal adenocarcinoma cell line in which the PAF1 protein, another subunit of PAF1c, has been replaced by an auxin-degradable chimera47 (Supplementary Fig. 6i), further supporting the notion that the PAF1c is directly involved in regulation of MHC class I genes. This evidence concerns the gene PAF1 and colorectal adenocarcinoma.