UBXN6 collaborates with protein tyrosine phosphatase 4a2 (PTP4A2) to assemble the endo-lysosomal damage response (ELDR) complex, thereby promoting autophagosome formation and facilitating the clearance of damaged lysosomes [114].UBXN4 exhibits a negative correlation with macrophage-related markers, suggesting its potential as a prognostic marker for lung cancer [115]. This evidence concerns the gene PTP4A2 and lung cancer.