Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) are characterized by tau and/or TAR DNA-binding protein 43 (TDP-43) inclusions while α-synuclein (α-syn) accumulates in the brain of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients1. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.