Current studies have identified several activation pathways or substances: low osmolality and 4α-forbol-decanoate can modulate TRPV4 channels in white adipocytes, resulting in increased intracellular Ca2+ concentrations [94], and altering body weight in obese asthmatics by affecting energy storage in WAT will help patients improve asthma symptoms (Figs. 2, 3). This evidence concerns the gene TRPV4 and asthma.