On the other hand, AD PRS was not a predictor of RNFL or GCIPL thickness, despite three ADD candidate SNPs’ being associated with RNFL (rs587709, within the LILRB2 gene) and GCIPL (rs7384878, within the SPDYE3 gene, and rs6586028, within the TSPAN14 gene). Here, SPDYE3 is linked to Alzheimer disease.