The guidelines of the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) suggest that patients with obesity, T2D, and CKD need either glucagon-like peptide 1 receptor analogues (GLP1RA) or sodium-glucose cotransporter-2 inhibitors (SGLT2i). The gene discussed is SLC5A2; the disease is obesity due to melanocortin 4 receptor deficiency.