APLN and Alzheimer disease: Kyoto Encyclopedia of Genes and Genomes (KEGG) terms enrichment also revealed transcriptional alterations related to PI3K-AKT signaling pathway, apelin signaling pathway, TGF-beta signaling pathway, oxytocin signaling pathway, and alpha-linolenic acid metabolism, which participate in neuronal survival and differentiation as well as AD progression (Supplementary Fig. 6d, e)13–15.