APP and Alzheimer disease: As expected, light-treated AD mice exhibited cognition restoration in the behavioral tests (5xFAD + light: 63.466 ± 4.501% versus 5xFAD: 42.987 ± 3.839%, P = 0.00047 in NOR test; APP/PS1 + light: 65.312 ± 3.974% versus APP/PS1: 44.732 ± 6.231%, P = 0.01716 in NOR test).