Compared with untreated AD mice, light treatment decreased latency to find the platform in acquisition trials (5xFAD + light versus 5xFAD, P = 0.0000001; APP/PS1 + light versus APP/PS1, P < 0.0000001) and increased visits to platform location and visits to the target quadrant in probe test, without any effect on swimming velocity. Here, APP is linked to Alzheimer disease.