To explore the effect of mLVs modulation by light on the learning and memory ability of AD mice, we similarly conducted light treatment and performed OF, NOL, and NOR tests on 5xFAD mice (6 months, male) and APPswe/PS1ΔE9 (APP/PS1) mice (11 months, male) (Fig. 2a). This evidence concerns the gene APP and Alzheimer disease.