We observed that circPCNXL2 overexpression could promote the association between STRAP and MEK1/2 with no change in the level of their protein, on the contrary, circPCNXL2 knockdown attenuated the STRAP-MEK1/2 interaction in ICC cells (Fig. 5k-l). This evidence concerns the gene MAP2K1 and intrahepatic cholangiocarcinoma.