Additionally, RNA immunoprecipitation (RIP) showed that circPCNXL2 was remarkably enriched by Argonaute 2 (AGO2) antibody in HuCCT1 and RBE cells, suggesting that circPCNXL2 may function as a miRNA inhibitor in ICC. The gene discussed is AGO2; the disease is intrahepatic cholangiocarcinoma.