METTL3 and hepatocellular carcinoma: Moreover, several HBV-induced cancer-related signaling pathways in hepatocellular carcinoma were reported in extrahepatic tissue carcinogenesis as follows: (1) Wnt pathway [34]; (2) PI3K/Akt signaling pathway [29, 35]; (3) METTL3-mediated MYC mRNA m6A modification [36].