To understand why SHCBP1 was closely correlated with tumour proliferation, we first assessed its expression in human-derived cell lines, including immortalized bronchial epithelial (HBE), lung cancer (A549, NCI-H1299, NCI-H460, NCI-H292), HeLa, and 293wt cells. This evidence concerns the gene SHCBP1 and lung carcinoma.