SHCBP1 and neoplasm: Moreover, DNA damage induces the upregulation of SHCBP1 expression, and the antitumour effect is augmented by the combination of SHCBP1 inhibition with low-dose DNA-damaging agents, which induces tumour cells with unrepaired DNA damage, and especially those with P53 deficiency, to enter mitosis, triggering mitotic catastrophe.