SHCBP1 and neoplasm: Out of these, A549 showed the most significant apoptosis (Fig. 6I) and a more obvious phenomenon in senescence (Fig. 6J), indicating that tumour cells with low SHCBP1 expression were more sensitive to SHCBP1 intervention, but the different residual SHCBP1 levels after knockdown may also account for this phenomenon.