To determine the clinical significance of SHCBP1 in NSCLC, we analyzed publicly available datasets (TCGA, Oncomine, and TIMER), clinical lung cancer specimens, and LUAD tissue microarray data to examine SHCBP1 expression in tumour and normal tissues, and the correlation of SHCBP1 with patient clinical characteristics. The gene discussed is SHCBP1; the disease is non-small cell lung carcinoma.