GO, BP and KEGG pathway enrichment analysis of 346 genes highly correlated with SHCBP1 (r ≥ 0.5, p < 0.0001) showed involvement of mainly chromosome separation, DNA replication, cell cycle and DNA damage repair pathways (Fig. 1D, E), indicating that high SHCBP1 expression in tumour tissues may play a role in tumour cell cycle progression and related DNA damage repair function. The gene discussed is SHCBP1; the disease is neoplasm.