Consistently, we found that SHCBP1 knockdown induced multipolar spindle formation and delayed mitotic exit in tumour cells, which also caused moderate DNA damage in the treated tumour cells, and the downregulated NEK7 expression and upregulated ZW10 expression caused by the SHCBP1 inhibition may account for the disrupted mitosis. The gene discussed is NEK7; the disease is neoplasm.