NKX2-1 and neoplasm: Higher SHCBP1 expression were found in tumour tissues than in normal tissues of public database (Fig. 1A, B), and was significantly correlated with TNM clinical stage in patients with LUAD (all p < 0.05) (Table S1), positively correlated with MKI67 (proliferation marker), but negatively correlated with NKX2.1 (a differentiation marker) expression in tumour tissues (Fig. 1C).