Co-localization of SHCBP with γ- or α-tubulin in tumour cells continuously released from G2–M (RO3306) block at different time points showed that SHCBP1 changed from a diffuse and uniform nuclear distribution to aggregation in mitotic spindle-related sites when the cells entered the mitotic phase from interphase (Fig. 3A). The gene discussed is SHCBP1; the disease is neoplasm.