Another study examined the MRI scans of 100 breast cancer patients with a known CNS-disease, exhibiting a higher rate of occipital and cerebellar metastasis for HER2-positive and/or ER-positive tumors, and a higher rate of frontal, parietal and limbic region involvement for triple-negative tumors (P < 0.05) [24]. Here, ESR1 is linked to breast carcinoma.