BRCA1 and breast carcinoma: BRCA PVs are known to be correlated with younger age at diagnosis of breast cancer- median 38 years in BRCA1 mutation and 41 years in BRCA2 mutation, as compared to 43 years in non-BRCA mutated women, and for BRCA1- a higher incidence of high-grade tumors (87%) and triple-negative disease (73%) [15, 16].