In the US results, the ACE inhibitor group showed a higher risk of schizophrenia occurrence than the ARB group, including the total population and the subgroup (total population: calibrated HR 1.29 [95% CI, 1.08–1.54]; subgroup: calibrated HR 1.24 [95% CI, 1.01–1.52]). This evidence concerns the gene ACE and schizophrenia.