Overall, the meta-analysis result showed no significant difference in schizophrenia occurrence between the ACE inhibitor and ARB groups (IR 0.43/1 000 PY, 0.33/1 000 PY, summary HR 1.15 [95% CI, 0.99–1.33], P =.06) (Fig. 3). This evidence concerns the gene ACE and schizophrenia.