Similarly, we found the relevant evidence of alteration or association of transcription factors CENPA [84], DDIT3 [85], JUNB [86, 87], TFDP1 [88], ZBTB16 [89], ZNF467 [90] for the alteration of diverse cellar process and function to develop the COVID-19 pathogenesis and associated respiratory disorders. The gene discussed is ZBTB16; the disease is COVID-19.