Likewise, we searched the practical importance of respiratory disorders-related transcription factors (ARID3A, BCL6, E2F1, FOXO1, FOXO3, RARA, RXRA, CENPA, DDIT3, JUNB, MAX, MEOX2, NPAS1, PHF1, PITX1, TFDP1, ZBTB16, ZNF467) identified by or network to validate their importance in COVID-19 respiratory disorders development. The gene discussed is DDIT3; the disease is COVID-19.