Likewise, we searched the practical importance of respiratory disorders-related transcription factors (ARID3A, BCL6, E2F1, FOXO1, FOXO3, RARA, RXRA, CENPA, DDIT3, JUNB, MAX, MEOX2, NPAS1, PHF1, PITX1, TFDP1, ZBTB16, ZNF467) identified by or network to validate their importance in COVID-19 respiratory disorders development. This evidence concerns the gene FOXO3 and respiratory system disorder.