Likewise, we searched the practical importance of respiratory disorders-related transcription factors (ARID3A, BCL6, E2F1, FOXO1, FOXO3, RARA, RXRA, CENPA, DDIT3, JUNB, MAX, MEOX2, NPAS1, PHF1, PITX1, TFDP1, ZBTB16, ZNF467) identified by or network to validate their importance in COVID-19 respiratory disorders development. This evidence concerns the gene E2F1 and respiratory system disorder.